Mp52-20 Kidney Allograft Nephrectomy – a Retrospective Review of Indications and Surgical Outcomes: Single Institution, 18 Years of Experiences
Year: 2020
Type: article
Study design: Observational Study
Abstract: golden triangle.The recipient surgeries were also done by experienced surgeons and the anastomoses were done using stented extravesical tunneled Lich-Gregoire technique.Twelve cases of ureterovesical leak were identified and compared with 48 controls with respect to various factors which may have predicted leak; along with recording of patient and graft survival outcomes.RESULTS: Twelve out of 790 (1.5%) patients presented with ureterovesical leak in the postoperative period requiring intervention.Variables like gender, basic disease, diabetic status, previous transplantation, choice of induction immunosuppression, urine output and duration on hemodialysis were comparable between the groups.Factors such as acute rejection, ABO incompatibility, complete HLA mismatch, older age and plasmapheresis were found to be significant in univariate analysis.Plasmapheresis therapy, complete HLA mismatch and older age were significant in multivariate analysis.Plasmapheresis demonstrated highest risk of leak.Patient survival was also considerably reduced in the leak group but the graft survival was comparable.None of the patients required surgical intervention as leak resolved in all these patients by conservative therapy.CONCLUSIONS: Acute rejection and anti-rejection therapy; specifically, heavy immunosuppression using plasmapheresis and IV immunoglobulins might have significant association with ureteric leak.The survival outcomes showed significant reduction in the patients' overall survival with ureteric leak; however, the graft survival outcomes were comparable.
Source: The Journal of Urology
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3023870680