Work

Cobalt-Catalyzed E -Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand

Year: 2020

Type: article

Abstract: An efficient method to access (E)-trisubstituted alkenes is reported via cobalt-catalyzed isomerization of 1,1-disubstituted alkenes using a phosphine-amido-oxazoline ligand. The reaction could also convert mono- and 1,2-disubstituted alkenes to (E)-internal alkenes with benzylic selectivity. This protocol is atom-economy and operationally simple and uses readily available starting materials with good functional tolerance. This catalytic system could be scaled up to gram scale smoothly with a catalyst loading of 0.1 mol %.

Source: ACS Omega

DOI: 10.1021/acsomega.0c00951

Authors: Hongmei Liu, Cheng Cai, Yanghao Ding, Jianhui Chen, Bosheng Liu, Yuanzhi Xia

Institution: Wenzhou University

Language: English

Topic: Organometallic Complex Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $750

Funders: National Natural Science Foundation of China, Wenzhou Municipal Science and Technology Bureau, Wenzhou University