OpenAlex | EGFR-A763_Y764insFQEA Is a Unique Exon 20 Insertion Mutation That Displays Sensitivity to Approved and In-Development Lung Cancer EGFR Tyrosine Kinase Inhibitors

EGFR-A763_Y764insFQEA Is a Unique Exon 20 Insertion Mutation That Displays Sensitivity to Approved and In-Development Lung Cancer EGFR Tyrosine Kinase Inhibitors

Work

Year: 2020

Type: article

Abstract: The EGFR-A763_Y764insFQEA is a unique exon 20 insertion mutation (~5% to 6% of exon 20 insertions), which, at the structural and enzyme kinetic level, more closely resembles EGFR tyrosine kinase inhib... more

Source: JTO Clinical and Research Reports

Authors Pedro Eduardo Nascimento Silva Vasconcelos, Carol Gergis, Hollis Viray, Andreas Varkaris, Masanori Fujii +5 more

Institutions Beth Israel Deaconess Medical Center, Harvard University, Chiba Cancer Center

Cites: 15

Cited by: 70

Related to: 10

FWCI: 7.676

Citation percentile (by year/subfield): 100

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

Sustainable Development Goal Good health and well-being

Open Access status: gold

APC paid (est): $2,000

Funders U.S. Department of Defense, National Cancer Institute