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Role of sphingolipid metabolism in neurodegeneration

Year: 2020
Type: review
Abstract: Sphingolipids are a class of lipids highly enriched in the central nervous system (CNS), which shows great diversity and complexity, and has been implicated in CNS development and function. Alterations in sphingolipid metabolism have been described in multiple diseases, including those affecting the central nervous system (CNS). In this review, we discuss the role of sphingolipid metabolism in neurodegeneration, evaluating its direct roles in neuron development and health, and also in the induction of neurotoxic activities in CNS-resident astrocytes and microglia in the context of neurologic diseases such as multiple sclerosis and Alzheimer's disease. Finally, we focus on the metabolism of gangliosides and sphingosine-1-phosphate, its contribution to the pathogenesis of neurologic diseases, and its potential as a candidate target for the therapeutic modulation of neurodegeneration.
DOI: 10.1111/jnc.15044
Authors: Manal Alaamery, Nour Albesher, Nora Aljawini, Moneera Alsuwailm, Salam Massadeh, Michael A. Wheeler, Chun‐Cheih Chao, Francisco J. Quintana
Institutions: King Abdulaziz City for Science and Technology, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, National Guard Health Affairs, Brigham and Women's Hospital, Harvard University, Broad Institute
Language: English
Open Access status: green
Funders: National Multiple Sclerosis Society, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences
OpenAlex ID: W3024990779
FWCI: 1.311
Cites: 113
Cited by: 128
Related to: 10