Work

Calcium-Dependent Regulation of Ion Channels.

Year: 2006

Type: article

Abstract: Calcium plays an important role in regulating hundreds of biological processes due to its primary role as one of the most ubiquitous second messengers. As a result, the levels of calcium are tightly regulated as are the peak and trough calcium concentrations during a calcium signal. Calcium levels are controlled via a variety of feedback mechanisms and exchangers/transporters. Here the role of calcium in the feedback regulation of ion channel function is reviewed, with an emphasis on the molecular mechanisms governing calcium-dependent function. In particular, the role of calcium in the regulation of voltage-gated sodium, calcium, and potassium channels are reviewed as well as its effects on the ryanodine receptor.

Source: PubMed

Authors: Vikas N Shah, Benjamin Chagot, Walter J Chazin

Institution: Vanderbilt University Medical Center

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: Medical Scientist Training Program, S100 Proteins: Structural Basis of Functional Properties, STRUCTURAL BIOLOGY OF EF-HAND CALCIUM BINDING PROTEINS, Molecular Basis of Local Anesthesia

OpenAlex ID: W3025002918

FWCI: 0.246

Cites: 115

Cited by: 32

Related to: 10