Measurement and characterization of distinctive clinical phenotypes using the Frontotemporal Lobar Degeneration Module (FTLD‐MOD)
Year: 2020
Type: article
Abstract: INTRODUCTION: The Frontotemporal Lobar Degeneration Module (FTLD-MOD) was designed as a research neuropsychological battery to evaluate clinical symptoms associated with FTLD. This study investigated whether the FTLD-MOD could differentiate between primary progressive aphasia (PPA) and behavioral variant frontotemporal dementia (bvFTD), two distinct FTLD-related syndromes. METHODS: Retrospective analysis was conducted on data collected from the initial visit of 165 subjects with PPA, 268 with bvFTD, and 251 cognitively normal controls from the National Alzheimer's Coordinating Center. Generalized linear models were used to compare group performance patterns on FTLD-MOD tasks of language, behavior, and memory. RESULTS: PPA participants showed significantly poorer performances on all language tasks whereas bvFTD participants demonstrated poorer performances on most behavioral measures. There were no differences in memory performances. Descriptive data on participant groups are provided for reference. DISCUSSION: Findings from this multi-center sample suggest that the FTLD-MOD can differentiate between distinctive clinical phenotypes commonly associated with FTLD.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.12098
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Awards: G1218215880, Michigan Alzheimer's Disease Core Center, UC Davis Alzheimer's Disease Core Center, Indiana Alzheimer Disease Center, Wake Forest Alzheimer's Disease Core Center, University of Kentucky Alzheimer's Disease Core Center, Neurobiology of Alzheimer's Disease and Aging, Alzheimer's Disease Research Center, 1Florida Alzheimer's Disease Research Center, National Alzheimer's Coordinating Center, UCSD Alzheimer's Disease Research Center P50, Alzheimer's Disease Research Center, Alzheimer's Disease Core Center, The Alzheimer's Disease Research Center at the University of California, Irvine, Stanford Alzheimer's Disease Research Center, Oregon Alzheimer's Disease Center, Rush Alzheimer's Disease Core Center, Alzheimer's Disease Core Center, Alzheimer's Disease Research Center - Overall, Wisconsin Alzheimer's Disease Research Center, University of Kansas Alzheimer's Disease Core Centers, Alzheimer's Disease Research Center, Alzheimer Disease Research Center, Yale Alzheimer Disease Research Center, Arizona Alzheimer's Disease Core Center, Johns Hopkins Alzheimer's Disease Research Center, Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes, Boston University Alzheimer's Disease Center, Alzheimer's Disease Research Center, Massachusetts Alzheimer's Disease Research Center, Alzheimer's Disease Core Center, Emory Alzheimer's Disease Center, University of Florida - Mt. Sinai Medical Center AD Research Center, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, University of Kansas Alzheimer's Disease Research Center (KU ADRC), Alzheimer Disease Research Center, Alzheimer's Disease Research Center, Stanford Alzheimer's Disease Research Center, Mount Sinai Alzheimer's Disease Research Center, University of Washington Alzheimer's Disease Research Center, Alzheimer's Disease Research Centers, National Alzheimer's Coordinating Center, Goizueta Alzheimer's Disease Research Center, The Alzheimer's Disease Research Center at the University of California, Irvine, New Approaches to Dementia Heterogeneity, Mayo Alzheimer's Disease Research Center
OpenAlex ID: W3025548642