Year: 2020
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging. METHODS: We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals. RESULTS: The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns. DISCUSSION: We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.12108
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Awards: Multimorbidity and Aging: Rochester Epidemiology Project, Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial Findings, Alzheimers Disease Patient Registry, G3930010334, G4741916379, Evaluating and Extending Our Hypothetical Model of Alzheimer's Biomarkers, G5484535055, G5900136256, Development, Validation, and Application of an Imaging based CVD Scale, Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology Project, G824560934, Brain Aging and Alzheimer's Biomarker Classification Using Amyloid PET, tau PET, and Neurodegeneration on MRI: Developing the ATN system, G8611190880, Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkers, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Investigating Resistance and Resilience Mechanisms in Alzheimer’s Disease, Mayo Alzheimer's Disease Research Center
OpenAlex ID: W3025587115