Work

Prescription Opioid Analgesics Increase Risk of Major Depression: New Evidence, Plausible Neurobiological Mechanisms and Management to Achieve Depression Prophylaxis.

Year: 2014

Type: article

Abstract: provides clear evidence that prescription opioid used for non-cancer, non-HIV pain increases significantly the risk of development of major depressive disorder in opioid naïve individuals with no recent history of depression and substance used disorders. The risk of depression increased as the dose and/or the duration of opioid use increased. The purpose of the present paper is to elucidate the details of this study, to examine potential neurobiological mechanisms responsible for the depressogenic effect of opioid analgesics, and to discuss management options that emphasize depression prophylaxis.

Source: Europe PMC (PubMed Central)

Authors: Katherine Semenkovich, Ravikumar Chockalingam, Jeffrey F Scherrer, Vassilis N Panagopoulos, Patrick J Lustman, John M Ray, Kenneth E Freedland, Dragan M Svrakic

Institutions: St. Louis VA Medical Center, John Cochran VA Medical Center, Washington University in St. Louis, VA St. Louis Health Care System, Veterans Administration

Language: English

Topic: Opioid Use Disorder Treatment

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3025636461

FWCI:

Cites: 33

Cited by: 30

Related to: 10