Work

Bioinorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancer

Year: 2020

Type: article

Abstract: in gut and lead to reduction in MDSC amplification in the tumor site. In addition, antigen-presenting cells (APCs) were activated by M13 phages to further awaken the host immune system for CRC suppression. M13@Ag combined with immune checkpoint inhibitors (α-PD1) or chemotherapeutics (FOLFIRI) significantly prolonged overall mouse survival in the orthotopic CRC model.

Source: Science Advances

DOI: 10.1126/sciadv.aba1590

Authors: Xue Dong, Pei Pan, Di-Wei Zheng, Peng Bao, Xuan Zeng, Xian-Zheng Zhang

Institution: Wuhan University

Language: English

Topic: Bacterial Cancer Therapy

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500