Protosappanin a inhibits osteoclastogenesis via reducing oxidative stress in RAW264.7 cells.
Year: 2017
Type: article
Abstract: , our results demonstrated that PrA supplementation improved some serum oxidative markers, including malondialdehyde (MDA) and reduced glutathione (GSH), and inhibited some osteoclastic markers, such as CTX-1 and TRAP. Importantly, it ameliorated the micro-architecture of trabecular bones by micro-CT assay. In summary, these findings showed that protection by PrA against osteoporosis is associated with a reduction in oxidative stress, suggesting that PrA may be useful in bone resorption related diseases, especially osteoporosis.
Source: PubMed
Authors: Qiang Huang, Rui-Ying Meng, Yan-Wei Yang, Meng Li, Fei Wang, Wei-Wei Shen, Xiao-Wen Deng, Shun-Gang Zhou, Yun Xue, Qiu-Ming Gao
Institution: Lanzhou Army General Hospital
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3026425066