Elevated nuclear CDK6 is associated with an unfavorable prognosis in lung adenocarcinoma patients.
Year: 2017
Type: article
Study design: Observational Study
Abstract: AIMS: It has been recently reported that cyclin-dependent kinase 6 (CDK6) is abnormally expressed in several human malignant tumors; however, CDK6 nuclear expression has not been fully studied in lung adenocarcinoma. We determined the correlation between the level of CDK6 expression and clinicopathologic data in lung adenocarcinoma patients, including survival. METHODS AND RESULTS: =0.004). Multivariate analysis indicated that high expression of nuclear CDK6 was an independent prognostic indicator of patient survival. CONCLUSIONS: Our findings demonstrate that nuclear CDK6 protein is overexpressed and plays a detrimental role in disease progression and poor outcome with lung adenocarcinoma patients.
Source: PubMed
Authors: Huiling Li, Junyi Zhang, Yingying Xie
Language: English
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3026699364