Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.
Year: 2019
Type: article
Abstract: Sirt6 is a vital member of the Sirtuin family that plays a key role in cellular apoptosis, aging, DNA damage repair, telomere homeostasis and integrity, energy metabolism, glucose homeostasis, and gene regulation. In recent studies, Sirt6 is down-regulated in several cancers and predicted to be a tumor suppressor, but as a tumor oncogene in other cancers. In this study, we explored the specific role of Sirt6 in human renal cell carcinoma (RCC). We found that Sirt6 was up-expressed in renal tumor tissues and cells. Sirt6 silence in RCC led to G1/S phase arrest, a rise in apoptosis and a decrease in cell viability, as well as an enhancement of chemotherapeutic sensitivity. In conclusion, these findings suggest that Sirt6 acted as an oncogene in human RCC and it could be a potential target for RCC treatment.
Source: Europe PMC (PubMed Central)
Authors: Yu Ding, Sisi Wu, Yuwei Huo, Xuemei Chen, Li Chai, Yan Wang, Xiangxiu Wang, Guonian Zhu, Wei Jiang
Institutions: Sichuan University, West China Hospital of Sichuan University
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3026720797