Work

The RNA-binding protein Sam68 is critical for non-small cell lung cancer cell proliferation by regulating Wnt/β-catenin pathway.

Year: 2017

Type: article

Abstract: loss-of-function studies showed that knockdown of Sam68 inhibited cell proliferation, colony formation and cell cycle progression in NSCLC cells. Moreover, our results clarified that knockdown of Sam68 could suppress NSCLC cell proliferation via the inhibition of Wnt/β-catenin pathway. To conclude, our results demonstrated that upregulation of Sam68 in NSCLC resulted in poor prognosis, and it promoted cell proliferation via activating Wnt/β-catenin signaling pathway, which could serve as a novel biomarker for the prognosis and therapy of NSCLC.

Source: PubMed Central

Authors: Xuebing Li, Xuexia Zhou, Feng Hua, Yaguang Fan, Lingling Zu, Yuli Wang, Wang Shen, Hongli Pan, Qinghua Zhou

Institutions: Tianjin Medical University General Hospital, Tianjin Medical University, Shandong Tumor Hospital, Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3027238430

FWCI: 0.224

Cites: 32

Cited by: 7

Related to: 10