Work

Kinetic Study of Disulfonimide-Catalyzed Cyanosilylation of Aldehydes by Using a Method of Progress Rates

Year: 2020

Type: article

Abstract: Kinetic study of organic reactions, especially multistep catalytic reactions, is crucial to in-depth understanding of reaction mechanisms. Here we report our kinetic study on the chiral disulfonimide-catalyzed cyanosilylation of an aldehyde, which revealed that two molecules of TMSCN are involved in the rate-determining C–C bond-forming step. In addition, the apparent activation energy, enthalpy of activation, and entropy of activation were deduced through a study of the temperature dependence of the reaction rates. More importantly, a novel and efficient method that makes use of the progress rates was developed to treat kinetic data obtained by continuous monitoring of the progress of a reaction by in situ FTIR.

Source: Synlett

DOI: 10.1055/s-0040-1707129

Authors: Zhipeng Zhang, Martin Klussmann, Benjamin List

Institutions: East China University of Science and Technology, Max-Planck-Institut für Kohlenforschung

Language: English

Topic: Chemical Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Max-Planck-Gesellschaft, Fundamental Research Funds for the Central Universities

Awards: G1159953824, G2023960946, G6129538325