Work

Accelerated development of instability-induced osteoarthritis in transgenic mice overexpressing SOST.

Year: 2017

Type: article

Abstract: OBJECTIVE: mice. METHODS: mice and their wild-type (WT) littermates were subjected to DMM or sham surgery. Knee joints were isolated to evaluate the cartilage damage and the subchondral bone plate thickness at 2 and 8 weeks post-surgery. The changes of chondrocyte anabolic and catabolic responses after IL-1β or TNFα stimulation, β-catenin signaling and apoptosis were also measured. RESULTS: mice may be associated with reduced β-catenin signaling and increased chondrocyte apoptosis. CONCLUSION: Overexpressing SOST led to accelerated development of instability-induced OA. Our data further highlight that cartilage homeostasis requires finely tuned Wnt signaling.

Source: PubMed

Authors: Sheng Zhou, Yuxiang Ge, Yixuan Li, Zhengyuan Bao, Chen Yao, Huajian Teng, Qing Jiang

Institutions: Nanjing Drum Tower Hospital, Nanjing University, Nanjing Medical University, Model Animal Research Center

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3027338798

FWCI:

Cites: 36

Cited by: 5

Related to: 10