Aberrant RASSF5 gene transcribed region hypermethylation in pediatric hepatoblastomas.
Year: 2018
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Aberrant DNA methylation plays an important role in cancer and has been recognized to contribute to the activity of oncogenes and inactivity of tumor suppressor genes. RAS association domain family (RASSF) members have been shown to be epigenetically silenced by promoter methylation in cancers, including hepatoblastoma. METHODS: We assessed the methylation patterns in the gene of RASSF5 from hepatoblastoma tissue samples harvested from patients using high-throughput mass spectrometry on a matrix-assisted laser desorption/ionization time-of-flight mass array. RESULTS: Hypermethylation was found in the RASSF5 gene transcribed regionand was correlated with downregulation of RASSF5 RNA expression levels in the hepatoblastoma samples. CONCLUSIONS: The results indicate that aberrant methylation of RASSF5 may contribute to its downregulated mRNA expression in hepatoblastoma.
Source: Europe PMC (PubMed Central)
Institutions: Fudan University, Children's Hospital of Fudan University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3027561996