Year: 2020
Type: review
Abstract: Recent large-scale GWAS and large epidemiologic studies have accelerated the discovery of genes and environmental factors that contribute to the risk of keratinocyte carcinoma (KC), which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This Review summarizes the genomic regions associated with SCC and BCC risk, examines the genetic overlap between SCC and BCC, and discusses biological pathways involved in SCC and BCC development. Next, we review environmental factors that are associated with KC risk, including those that are shared between SCC and BCC as well as others that associated with only one type of KC. We conclude with a critical appraisal of current research and potential directions for future research.
Source: JCI Insight
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,100
Awards: G1386795956, G1869199916, The Role of Refractive Error in the Etiology of Glaucoma, PQ3 Cutaneous squamous cell carcinoma: Integrating germline and somatic alterations that underlie tumor progression, Genome-wide association study of cutaneous squamous cell carincoma, Genetic Etiology of Abdominal Hernia Susceptibility, G6812040023, G708725164, Patient oriented research and mentoring program in dermatologic diseases, The Role of Genetic Risk Factors in Keratinocyte Carcinoma Susceptibility
OpenAlex ID: W3027642447