Work

Genome-wide SNP and InDel mutations in Mycobacterium tuberculosis associated with rifampicin and isoniazid resistance.

Year: 2018

Type: article

Abstract: OBJECTIVE: infection. This study aimed to characterize the single nucleotide polymorphisms (SNPs) and insertion and deletion (InDel) mutations associated with isoniazid and rifampicin resistance. METHODS: strain H37Rv was cultured and treated with isoniazid or rifampicin for generations. Total DNA samples from different generations were extracted for construction of DNA library, and the SNP and InDel mutation in different samples were detected by whole genome sequencing. Bioinformatics analysis such as phylogenetic tree and heap map were also performed. RESULTS: , showing distinct mutation patterns. CONCLUSION: .

Source: PubMed

Authors: Haicheng Li, Huixin Guo, Tao Chen, Li Yu, Yuhui Chen, Jiao Zhao, Huimin Yan, Mu Chen, Qi Sun, Chenchen Zhang, Lin Zhou, Liang Chen

Institutions: Center for Tuberculosis Control of Guangdong Province, Jinan University, Guangdong Medical College, Sixth Affiliated Hospital of Sun Yat-sen University

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3027718114

FWCI: 0.191

Cites: 40

Cited by: 5

Related to: 10