Work

Targeting long non-coding RNA HERC2P3 inhibits cell growth and migration in human gastric cancer cells.

Year: 2017

Type: article

Abstract: . The results demonstrated that HERC2P3 silencing inhibited cell growth and migration, although it only had a weak effect on cell growth. Western blot analysis revealed that Akt phosphorylation level could be reduced when HERC2P3 was knocked down, indicating Akt signaling may be involved in the HERC2P3-mediated tumor development. In addition, we analyzed the expression of HERC2P3 through quantitative RT-PCR in 30 paired gastric cancer samples and found HERC2P3 was up-regulated in gastric adenocarcinoma tissues compared with corresponding non-tumor tissues. Taken together, our results demonstrate that the abrogation of HERC2P3 could suppress tumor cell growth and migration, with important implication for validating HERC2P3 as a potential target for human gastric cancer therapy.

Source: PubMed

Authors: Jingde Chen, Hui Cai, Yongsong Xie, Hong Jiang

Institutions: Tongji University, Shanghai East Hospital, Second Affiliated Hospital of Zhejiang University, Zhejiang University, Dalian Medical University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3027722241

FWCI:

Cites: 25

Cited by: 4

Related to: 10