Chlamydia Lipooligosaccharide Has Varied Direct and Indirect Roles in Evading both Innate and Adaptive Host Immune Responses
Year: 2020
Type: article
Abstract: Chlamydia bacteria are obligate intracellular pathogens which can cause a variety of disease in humans and other vertebrate animals. To successfully complete its life cycle, Chlamydia must evade both intracellular innate immune responses and adaptive cytotoxic T cell responses. Here, we report on the role of the chlamydial lipooligosaccharide (LOS) in evading the immune response. Chlamydia infection is known to block the induction of apoptosis. However, when LOS synthesis was inhibited during Chlamydia trachomatis infection, HeLa cells regained susceptibility to apoptosis induction following staurosporine treatment.
Source: Infection and Immunity
DOI: 10.1128/iai.00198-20
Authors: Xisheng Wang, Daniel D. Rockey, Brian P. Dolan
Institution: Oregon State University
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: The Role of Ubiquitin and Ubiquitin-Like Molecules in Direct Antigen Presentation, Analysis of chlamydial recombination in vivo, Chlamydia-induced host protein degradation and its impact on the adaptive immune response., LpxC inhibitors as a novel class of antibiotics against N. gonorrhoeae, G9000110922, G9000126061
OpenAlex ID: W3027850776