Abnormal β-catenin expression and reduced tumor-infiltrating T cells are related to poor progression in non-small cell lung cancer.
Year: 2017
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: This study was to identify the relationship between the expression of β-catenin and CD8+ T cells infiltration in non-small cell lung cancer (NSCLC). METHODS: A total of 100 NSCLC patients undergoing lobectomy and lymph node dissection were enrolled in this study. The baseline demographics, histopathologic data, recurrence-free survival (RFS) period, and pathologic specimens preserved in paraffin were available for them. Immunohistochemistry (IHC) was carried out with resected, paraffin-embedded NSCLC tissues. Evaluation of tumor-infiltrating CD8+ T cells immunostaining was performed using a four-tiered scale according to the visual estimation on lymphocytes. RESULTS: =0.016). CONCLUSION: Abnormal β-catenin expression might suppress antitumor activity by decreasing tumor-infiltrating CD8+ T cells. Inhibition of β-catenin expression and/or activity might be used as a component of anti-cancer immunotherapy in the future.
Source: PubMed
Authors: Liang Ye, Huijuan Li, Hongying Wang, Hongbing Liu, Tangfeng Lv, Fang Zhang, Yong Song
Institutions: Nanjing First Hospital, Nanjing Medical University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3028109006