Work

Synergistic Action of Substituted Indole Derivatives and Clinically used Antibiotics Against Drug-Resistant Bacteria

Year: 2020

Type: article

Abstract: Aim: The current report describes the discovery of indole derivatives that synergize with standard antibiotics. Materials & methods: The antibacterial activities were determined using an optimized time–kill method, while viability of mammalian cells was assessed using the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Results: The synergy is observed with methicillin- and vancomycin-resistant Staphylococcus aureus bacterial strains, against which the standard antibiotics show no activities of their own. Our indole derivatives in combination with antibiotics lack toxicity toward mammalian cells, do not promote the evolution of resistance of S. aureus in comparison to clinically established antibiotics, and likely work by permeabilizing bacterial cell membranes. Conclusion: The above-mentioned findings demonstrate the potential clinical applications of our indole derivatives.

Source: Future Microbiology

DOI: 10.2217/fmb-2019-0094

Authors: Danielle N Turner, Leslie Edwards, Alexander Kornienko, Liliya V Frolova, Snezna Rogelj

Institutions: New Mexico Institute of Mining and Technology, Texas State University

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences