Substance Use and Depression Among Patients Adherent and Non-adherent to Antiretroviral Therapy
Year: 2016
Type: article
Study design: Observational Study
Abstract: The aim of the study was to determine the main predictors of leaving antiretroviral therapy by HIV-infected patients. We retrospectively assessed depression, hopelessness, substance use, viral load, and CD4+ counts of 120 patients who dropped out of antiretroviral therapy for ≥12 months (Lost-to-Care) and 120 who continued for ≥12 months (Engaged-in-Care). As expected, lost-to-care patients had higher viral load and, accordingly, fewer CD4+ lymphocytes. The level of depression, alcohol consumption, and injecting drug use in the 30 days preceding analysis was significantly higher in Lost-to-Care than in Engaged-in-Care HIV-infected patients. A binary logistic regression [χ2(4) = 64.27, p = 0.000] correctly classified 74.5% of participants as Lost-to-Care or Engaged-in-Care. The results indicate that substance use and depression are associated with antiretroviral therapy dropout. Evaluation of these factors with high degree of accuracy can predict patient’s antiretroviral therapy adherence. An integrated treatment for substance use and psychiatric disorders in HIV infected patients could reduce antiretroviral therapy dropout and improve outcomes of HIV treatment in Russia.
Source: Neurological Bulletin
Authors: Andrey Ustinov, Устинов Андрей Сергеевич, Anna Pecoraro, Пекораро Анна, Matthew J. Mimiaga, Мимиага Мэтью, Conall O’Cleirigh, О’Клейрих Конал, Steven A. Safren, Сафрен Стивен, Elena Blokhina, Блохина Елена Андреевна, E. Verbitskaya, Вербицкая Елена Владимировна, T. V. Yaroslavtseva, Ярославцева Татьяна Сергеевна, Dmitry Lioznov, Лиознов Дмитрий Анатольевич, Алена Суворова, Суворова Алёна Владимировна, A. Grinenko, Гриненко Александр Яковлевич, Edwin Zvartau, Звартау Эдвин Эдуардович, Evgeny Krupitsky, Крупицкий Евгений Михайлович, George Woody, Вуди Джордж E
Institutions: St.Petersburg V.M.Bekhterev Psychoneurological Research Institute, National Institute on Drug Abuse, University of Pennsylvania, Harvard University, Massachusetts General Hospital, First Pavlov State Medical University of St. Petersburg, Saint Petersburg Pasteur Institute, Russian Academy of Sciences, St. Petersburg Institute for Informatics and Automation
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3029497554