Work

Author response: Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

Year: 2020

Type: peer-review

Abstract: Mitochondrial electron transport chain dysfunction triggers the integrated stress response due to an asparagine deficiency downstream of impaired NADH oxidation in proliferating myoblasts, but not in differentiated myotubes.

Source: eLife

DOI: 10.7554/elife.49178.sa2

Authors: Eran Mick, Denis V Titov, Owen S Skinner, Rohit Sharma, Alexis A Jourdain, Vamsi K Mootha

Institutions: Broad Institute, Howard Hughes Medical Institute, Harvard University, Massachusetts General Hospital, Center for Systems Biology

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W3029689061

Cites:

Cited by: 1

Related to: 10