Work

Integrating Genetic and Genomic Testing Into Oncology Practice

Year: 2020

Type: article

Abstract: Genetic information, both germline and somatic, is an increasingly important consideration in therapeutic decision-making in cancer. Germline mutations in genes associated with increased cancer risk can identify those individuals without cancer who may benefit from enhanced screening and prevention strategies. In individuals with cancer, germline and somatic mutations may help to guide local and systemic management decisions. Here, we review considerations of these issues in selected cancer types.

Source: American Society of Clinical Oncology Educational Book

DOI: 10.1200/edbk_280607

Authors: Susan M. Domchek, Elaine Mardis, Jennifer W. Carlisle, Taofeek K. Owonikoko

Institutions: Abramson Cancer Center, University of Pennsylvania, The Ohio State University, Winship Cancer Institute

Language: English

Topic: BRCA gene mutations in cancer

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W3029703248

FWCI: 0.665

Cites: 32

Cited by: 9

Related to: 10