Work

Neuroglobin expression in rats after traumatic brain injury.

Year: 2012

Type: article

Abstract: In this study, we used a rat model of severe closed traumatic brain injury to explore the relationship between neuroglobin, brain injury and neuronal apoptosis. Real-time PCR showed that neuroglobin mRNA expression rapidly increased in the rat cerebral cortex, and peaked at 30 minutes and 48 hours following traumatic brain injury. Immunohistochemical staining demonstrated that neuroglobin expression increased and remained high 2 hours to 5 days following injury. The rate of increase in the apoptosis-related Bax/Bcl-2 ratio greatly decreased between 30 minutes and 1 hour as well as between 48 and 72 hours post injury. Expression of neuroglobin and the anti-apoptotic factor Bcl-2 greatly increased, while that of the proapoptotic factor decreased, in the cerebral cortex post severe closed traumatic brain injury. It suggests that neuroglobin might protect neurons from apoptosis after traumatic injury by regulating Bax/Bcl-2 pathway.

Source: Europe PMC (PubMed Central)

DOI: 10.3969/j.issn.1673-5374.2012.25.006

Authors: Xin Lin, Min Li, Aijia Shang, Yazhuo Hu, Xiao Yang, Ling Ye, Suyan Bian, Zhongfeng Wang, Dingbiao Zhou

Institutions: Chinese PLA General Hospital, Chinese People's Liberation Army, Academy of Military Medical Sciences, Fudan University, State Key Laboratory of Medical Neurobiology

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W303023729

FWCI:

Cites: 20

Cited by: 8

Related to: 10