Work

Site-selective, catalytic, and diastereoselective sp 3 C–H hydroxylation and alkoxylation of vicinally functionalized lactams

Year: 2020

Type: article

Abstract: C-H hydroxylation/alkoxylation protocols featuring dihydroisoquinolones, γ-, and δ-lactams, which bear vicinal stereocenters. The hydroxylation strategy utilizes oxygen, a waste-free oxidant and affords attractive fragments for potential drug discovery. Fe-catalyzed dehydrative coupling of the resulting tertiary alcohols with simple primary alcohols has led to the construction of highly versatile unsymmetrical dialkyl ethers.

Source: RSC Advances

DOI: 10.1039/d0ra03726e

Authors: Timothy K. Beng, Victoria Shearer, Rachel Davey, Ivianne Redman

Institution: Central Washington University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funder: Central Washington University