Work

Molecular Imaging of Cardiac Amyloidosis

Year: 2020

Type: review

Abstract: Transthyretin and light-chain amyloidosis are the 2 main causes of cardiac amyloidosis. Recent developments in molecular imaging have transformed our ability to diagnose transthyretin cardiac amyloidosis noninvasively and unmasked a hitherto unrecognized prevalence of the disease. This review summarizes the current and evolving imaging approaches, their molecular structural basis, and the gaps in imaging capabilities that have arisen as a result of parallel developments in pharmacotherapy delivering the first effective treatment options for this condition.

Source: Journal of Nuclear Medicine

DOI: 10.2967/jnumed.120.245381

Authors: Ahmad Masri, Syed Bukhari, Yvonne S. Eisele, Prem Soman

Institutions: Oregon Health & Science University, University of Pittsburgh

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute on Aging