Work

WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition

Year: 2020

Type: article

Abstract: BACKGROUND: mutations. In a previous study, we found that the E3 ubiquitin ligase WWP1 negatively regulates the function of PTEN. METHODS: variants. RESULTS: variants resulted in gain-of-function effects, which led to aberrant enzymatic activation with consequent PTEN inactivation, thereby triggering hyperactive growth-promoting PI3K signaling in cellular and murine models. CONCLUSIONS: as a cancer-susceptibility gene through direct aberrant regulation of the PTEN-PI3K signaling axis. (Funded by the National Institutes of Health and others.).

Source: New England Journal of Medicine

DOI: 10.1056/nejmoa1914919

Authors: Yu-Ru Lee, Lamis Yehia, Takahiro Kishikawa, Ying Ni, Brandie Leach, Jinfang Zhang, Nivedita Panch, Jing Liu, Wenyi Wei, Charis Eng, Pier Paolo Pandolfi

Institutions: Beth Israel Deaconess Medical Center, Cleveland Clinic, Harvard University, Cleveland Clinic Research, Wuhan University, Zhongnan Hospital of Wuhan University, Case Comprehensive Cancer Center, Case Western Reserve University, University of Turin

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Defense, Breast Cancer Research Foundation, Ambrose Monell Foundation, Cleveland Clinic, National Science Council, National Institutes of Health, Japan Society for the Promotion of Science, National Cancer Institute, DOD Prostate Cancer Research Program

Awards: G1489567593, G2080054145, G4119534169, PTEN in ontogenesis and tumor suppression, G5040825140, G5850682332, Targeting Tumor Suppressive Pathways for Cancer Therapy, Genetic and Signaling Pathways in Epithelial Thyroid Cancer

OpenAlex ID: W3032212186

FWCI: 4.053

Cites: 28

Cited by: 76

Related to: 10