Year: 2010
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Mitochondrial function is impaired in Parkinson's disease (PD) and may contribute to the pathogenesis of PD, but the causes of mitochondrial impairment in PD are unknown. Mitochondrial dysfunction is recapitulated in cell lines expressing mitochondrial DNA (mtDNA) from PD patients, implicating mtDNA variants or mutations, though the role of mtDNA variants or mutations in PD risk remains unclear. We investigated the potential contribution of mtDNA variants or mutations to the risk of PD. METHODS: We examined the possibility of a maternal inheritance bias as well as the association between mitochondrial haplogroups and maternal inheritance and disease risk in a case-control study of 168 multiplex PD families in which the proband and one parent were diagnosed with PD. 2-tailed Fisher Exact Tests and McNemar's tests were used to compare allele frequencies, and a t-test to compare ages of onset. RESULTS: The frequency of affected mothers of the proband with PD (83/167, 49.4%) was not significantly different from the frequency of affected females of the proband generation (115/259, 44.4%) (Odds Ratio 1.22; 95%CI 0.83-1.81). After correcting for multiple tests, there were no significant differences in the frequencies of mitochondrial haplogroups or of the 10398G complex I gene polymorphism in PD patients compared to controls, and no significant associations with age of onset of PD. Mitochondrial haplogroup and 10398G polymorphism frequencies were similar in probands having an affected father as compared to probands having an affected mother. CONCLUSIONS: These data fail to demonstrate a bias towards maternal inheritance in familial PD. Consistent with this, we find no association of common haplogroup-defining mtDNA variants or for the 10398G variant with the risk of PD. However, these data do not exclude a role for mtDNA variants in other populations, and it remains possible that other inherited mitochondrial DNA variants, or somatic mDNA mutations, contribute to the risk of familial PD.
Source: BMC Medical Genetics
Authors: the Parkinson Study Group - PROGENI Investigators, David K Simon, Nathan Pankratz, Diane K Kissell, Michael W Pauciulo, Cheryl A Halter, Alice Rudolph, Ronald F Pfeiffer, William C Nichols, Tatiana Foroud
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,380
Funders: Eli Lilly and Company, Brown University, University of Miami, Ohio State University, Northwestern University, University of Minnesota, Creighton University, Cleveland Clinic, University of Connecticut, Johns Hopkins University, University of Rochester, University of Cincinnati, University of South Florida, London Health Sciences Centre, NorthShore University HealthSystem, Ochsner Health, York University, University of Alberta, National Institutes of Health, Health Science Center, University of Tennessee, University of California, San Diego, University of California, Irvine, School of Medicine, Indiana University, National Human Genome Research Institute, National Institute of Neurological Disorders and Stroke
OpenAlex ID: W2085468780