Work

The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

Year: 2020

Type: review

Abstract: The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and biosynthesis. Enzymes in the PPP are reported to play important roles in many human diseases. In this review, we will discuss the role of the PPP in type 2 diabetes and cancer.

Source: Frontiers in Endocrinology

DOI: 10.3389/fendo.2020.00365

Authors: Tongxin Ge, Jiawen Yang, Shihui Zhou, Yuchen Wang, Yakui Li, Xuemei Tong

Institution: Shanghai Jiao Tong University

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950