Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19
Year: 2020
Type: article
Abstract: There is an urgent need for new therapeutic strategies to contain the spread of the novel coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely ill patients experience pathologic manifestations of acute respiratory distress syndrome (ARDS), and clinical reports demonstrate striking neutrophilia, elevated levels of multiple cytokines, and an exaggerated inflammatory response in fatal COVID-19. Mechanical respirator devices are the most widely applied therapy for ARDS in COVID-19, yet mechanical ventilation achieves strikingly poor survival. Many patients, who recover, experience impaired cognition or physical disability. In this review, we argue the need to develop therapies aimed at inhibiting neutrophil recruitment, activation, degranulation, and neutrophil extracellular trap (NET) release. Moreover, we suggest that currently available pharmacologic approaches should be tested as treatments for ARDS in COVID-19. In our view, targeting host-mediated immunopathology holds promise to alleviate progressive pathologic complications of ARDS and reduce morbidities and mortalities in severely ill patients with COVID-19.
Source: Frontiers in Pharmacology
Institutions: Oklahoma State University, Nepean Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Centre National de la Recherche Scientifique, Institut de Science et d'Ingénierie Supramoléculaires, Biotechnologie et Signalisation Cellulaire, Université de Strasbourg, National University of Singapore, National University Health System, University of Tennessee Health Science Center
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Funders: Oklahoma State University, Oklahoma Center for the Advancement of Science and Technology, Lupus Research Alliance, National University of Singapore, Deutsche Forschungsgemeinschaft, Agence Nationale de la Recherche, National Institutes of Health, National Institute of General Medical Sciences
OpenAlex ID: W3032985762