Work

Bacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior

Year: 2020

Type: review

Abstract: It is increasingly recognized that the gut microbiota profoundly influences many aspects of host development and physiology, including the modulation of brain development and behavior. However, the precise molecular mechanisms and signaling pathways involved in communication between the microbiota and the developing brain remain to be fully elucidated. Germline-encoded pattern-recognition receptors (PRRs) that recognize conserved microbial molecular signatures such as bacterial surface molecules (e.g., peptidoglycans, PGNs) have emerged as potential key regulators of gut microbiota-brain interactions. We highlight current evidence supporting multiple and essential roles for PGNs and their sensing molecules beyond innate immunity, extending to neurodevelopment and behavior. In addition, the possible implications of the PGN signaling pathway for the pathogenesis of neurodevelopmental disorders such as autism spectrum disorder (ASD) are considered.

Source: Trends in Molecular Medicine

DOI: 10.1016/j.molmed.2020.05.003

Authors: Ayoze Gonzalez-Santana, Rochellys Diaz Heijtz

Institutions: Karolinska Institutet, Inserm, Différenciation et Communication Neuronale et Neuroendocrine, Université de Rouen Normandie

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,000