Work

Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue

Year: 2020

Type: review

Abstract: Measuring molecular oxygen levels in vivo has been the cornerstone of understanding the effects of hypoxia in normal tissues and malignant tumors. Here we discuss the advances in a variety of partial pressure of oxygen ( ) measurements and imaging techniques and relevant oxygen thresholds. A focus on electron paramagnetic resonance (EPR) imaging shows the validation of treating hypoxic tumours with a threshold of ≤ 10 Torr, and demonstrates utility for in vivo oxygen imaging, as well as its current and future role in cancer studies. image

Source: The Journal of Physiology

DOI: 10.1113/jp278816

Authors: Inna Gertsenshteyn, Mihai Giurcanu, Peter Vaupel, Howard Halpern

Institutions: University of Chicago, University of Freiburg, German Cancer Research Center, University Medical Center Freiburg, Deutsches Konsortium für Translationale Krebsforschung

Language: English

Topic: Electron Spin Resonance Studies

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering