Work

Selective Binding of Complex Glycans and Glycoproteins in Water by Molecularly Imprinted Nanoparticles

Year: 2020

Type: article

Abstract: Synthetic receptors to recognize biological glycans are in great need for modern glycoscience and technology, but their design and synthesis have been a daunting challenge due to strong solvation of carbohydrates in water and structural complexity of the guest. Molecular imprinting in surfactant micelles with amide cross-linkers provides a convenient one-pot method to prepare nanoparticle receptors for glycosides, glycans, and glycoproteins, taking advantage of hydrogen-bonding interactions near the surfactant/water interface. Biologically competitive micromolar binding affinities were obtained in water and subtle structural differences of glycans could be distinguished.

Source: Nano Letters

DOI: 10.1021/acs.nanolett.0c01305

Authors: Milad Zangiabadi, Yan Zhao

Institution: Iowa State University

Language: English

Topic: Analytical chemistry methods development

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: G4564608278