Work

Monoclonal Gammopathy of Undetermined Significance (MGUS)—Not So Asymptomatic after All

Year: 2020

Type: article

Abstract: Monoclonal Gammopathy of Undetermined Significance (MGUS) is considered to be a benign precursor condition that may progress to a lymphoproliferative disease or multiple myeloma. Most patients do not progress to an overt condition, but nevertheless, MGUS is associated with a shortened life expectancy and, in a minority of cases, a number of co-morbid conditions that include an increased fracture risk, renal impairment, peripheral neuropathy, secondary immunodeficiency, and cardiovascular disease. This review aims to consolidate current evidence for the significance of these co-morbidities before considering how best to approach these symptoms and signs, which are often encountered in primary care or within a number of specialties in secondary care.

Source: Cancers

DOI: 10.3390/cancers12061554

Authors: Oliver C. Lomas, Tarek H. Mouhieddine, Sabrin Tahri, Irene M. Ghobrial

Institutions: Dana-Farber Cancer Institute, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,324