In vitro inhibitions of CYP2C9 and CYP3A4 by fractions isolated from Goji berry (Lycium barbarum) fruits
Year: 2019
Type: article
Abstract: Introduction Lycium barbarum L. , known as Goji, is widely used as a medicinal and functional food. Besides the positive therapeutic properties it possesses, it can inhibit enzymes involved in the metabolism of drugs and it can cause herb-drug interactions (HDIs). Aim The aim of the study is evaluation of the potential of polysaccharide and polyphenolic fractions isolated from L. barbarum fruits to inhibit the activity of CYP3A4 and CYP2C9 Materials and Methods The inhibitory effects of polysaccharide and polyphenolic fractions isolated from L. barbarum on CYP3A4 and CYP2C9 activity were determined using Vivid ® CYP3A4 and CYP2C9 Green Screening Kits. Results The both fractions inhibit the activity of investigated CYP isoenzymes. The polyphenolic fraction was more potent with IC 50 values of 0.119 mg/ml and 0.048 mg/ml against CYP3A4 and CYP2C9 respectively. The polysaccharide fraction has inhibited CYP3A4 and CYP2C9 with IC 50 values of 2.244 mg/ml and 4.094 mg/ml respectively. Conclusion The usage of beverages based on L.barbarum can lead to herb-drug interactions (HDIs). Further research in this direction will assess the significance of these interactions.
Authors: Kaloyan Georgiev, Maya Radeva-Ilieva
Institution: Medical University of Varna
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W3034608934