Year: 2020
Type: article
Abstract: Carbon nanomaterials such as graphene exhibit unique material properties including high electrical conductivity, surface area, and biocompatibility that have the potential to significantly improve the performance of electrochemical sensors. Since in-field electrochemical sensors are typically disposable, they require materials that are amenable to low-cost, high-throughput, and scalable manufacturing. Conventional graphene devices based on low-yield chemical vapor deposition techniques are too expensive for such applications, while low-cost alternatives such as screen and inkjet printing do not possess sufficient control over electrode geometry to achieve favorable electrochemical sensor performance. In this work, aerosol jet printing (AJP) is used to create high-resolution (∼40 μ m line width) interdigitated electrodes (IDEs) on flexible substrates, which are then converted into histamine sensors by covalently linking monoclonal antibodies to oxygen moieties created on the graphene surface through a CO 2 thermal annealing process. The resulting electrochemical sensors exhibit a wide histamine sensing range of 6.25–200 ppm (56.25 μ M–1.8 mM) and a low detection limit of 3.41 ppm (30.7 μ M) within actual tuna broth samples. These sensor metrics are significant since histamine levels over 50 ppm in fish induce adverse health effects including severe allergic reactions (e.g. Scombroid food poisoning). Beyond the histamine case study presented here, the AJP and functionalization process can likely be generalized to a diverse range of sensing applications including environmental toxin detection, foodborne pathogen detection, wearable health monitoring, and health diagnostics.
Source: 2D Materials
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Funders: National Science Foundation, U.S. Department of Commerce, W. M. Keck Foundation, Northwestern University, National Institute of Standards and Technology, Materials Research Science and Engineering Center, Harvard University, International Institute for Nanotechnology, Northwestern University, Division of Materials Research, Division of Chemical, Bioengineering, Environmental, and Transport Systems, Division of Electrical, Communications and Cyber Systems, Center for Hierarchical Materials Design, Air Force Research Laboratory
Awards: G1169090945, G1276186940, G2005393816, G2601846172, G2797879381, G2968215205, G298583090, G336680401, G3454132534, G3575805401, G4285583887, G4289625387, MRSEC: Center for Multifunctional Materials, G4912152698, G5112184052, G5218300437, G5793179256, NNCI: Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource, G6006880339, EAGER SitS: Bury and Forget Nitrogen Sensors Coupled With Remote Sensing for Soil Health, COLLABORATIVE RESEARCH: Disposable All-Graphene Microfluidic Biosensor System for Real-Time Foodborne Pathogen Detection in Food Processing Facilities, G6950106666, ADVANCED MATERIALS CENTER FOR EXCELLENCE: CENTER FOR HIERARCHICAL MATERIALS DESIGN (CHIMAD), G8073314406, G8230932042
OpenAlex ID: W3035126971