Work

Interspecies Differences in Tenofovir Alafenamide Fumarate Stability in Plasma

Year: 2020

Type: article

Abstract: Tenofovir (TFV) alafenamide fumarate (TAF) is an antiretroviral that has been evaluated in alternative drug delivery systems in several species. The ex vivo stability of TAF was evaluated, and TAF was stable in dog-, sheep-, and macaque-spiked plasma. A negative bias was observed in TAF recovery in rabbit-spiked plasma; there was complete loss of TAF and corresponding overestimation of TFV in rodent-spiked plasma. These data highlight considerations when evaluating TAF and TFV concentrations in preclinical studies.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00930-20

Authors: Teresa L. Parsons, Kevin N. Gwenden, Mark A. Marzinke

Institution: Johns Hopkins University

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Center for AIDS Research, Johns Hopkins University, National Institute of Allergy and Infectious Diseases