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Biomarkers and Strategy to Detect Preinvasive and Early Pancreatic Cancer: State of the Field and the Impact of the EDRN

Year: 2020
Type: article
Abstract: Patients afflicted with pancreatic ductal adenocarcinoma (PDAC) face a dismal prognosis, but headway could be made if physicians could identify the disease earlier. A compelling strategy to broaden the use of surveillance for PDAC is to incorporate molecular biomarkers in combination with clinical analysis and imaging tools. This article summarizes the components involved in accomplishing biomarker validation and an analysis of the requirements of molecular biomarkers for disease surveillance. We highlight the significance of consortia for this research and highlight resources and infrastructure of the Early Detection Research Network (EDRN). The EDRN brings together the multifaceted expertise and resources needed for biomarker validation, such as study design, clinical care, biospecimen collection and handling, molecular technologies, and biostatistical analysis, and studies coming out of the EDRN have yielded biomarkers that are moving forward in validation. We close the article with an overview of the current investigational biomarkers, an analysis of their performance relative to the established benchmarks, and an outlook on the current needs in the field. The outlook for improving the early detection of PDAC looks promising, and the pace of further research should be quickened through the resources and expertise of the EDRN and other consortia.
DOI: 10.1158/1055-9965.epi-20-0161
Authors: Ying Liu, Sukhwinder Kaur, Ying Huang, Johannes F. Fahrmann, Jo Ann Rinaudo, Samir M. Hanash, Surinder K. Batra, Aatur D. Singhi, Randall E. Brand, Anirban Maitra, Brian B. Haab
Institutions: Van Andel Institute, Nebraska Medical Center, University of Nebraska Medical Center, Fred Hutch Cancer Center, The University of Texas MD Anderson Cancer Center, National Cancer Institute, University of Pittsburgh Medical Center
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: green
Awards: MD Anderson Cancer Center SPORE in Gastrointestinal Cancer, Subpopulations of Pancreatic Cancer Cells Defined by Glycan Markers, Imaging and Molecular Correlates of Progression in Cystic Neoplasms of the Pancreas, EDRN:Data Management and Coordinating Center, Detection and prognosis of early-stage pancreatic cancer by interdependent plasma markers, Translational Applications in an Animal Model of Pancreatic Cystic Neoplasm and Cancer, The Early Detection Research Network: Data Management and Coordinating Center, Pancreatic Cancer Detection Consortium, Clinical Validation Center for Early Detection of Pancreatic Cancer, Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma
OpenAlex ID: W3035524190
FWCI: 0.812
Cites: 83
Cited by: 17
Related to: 10