Work

Prodrug Systems (I): Lipid-Based Doxorubicin Prodrugs and Their Nanodelivery Systems

Year: 2020

Type: article

Abstract: Using natural lipids to covalently connect with antitumor agents to construct lipid-based molecular prodrugs and their nanosystems is a promising research frontier for sustainable medicinal chemistry, nanobiotechnology and tumor chemotherapy.This paper reviewed recent progress of lipid-based doxorubicin (molecular) prodrugs and their nanodelivery systems, including lipid-doxorubicin prodrugs, stimuli-responsive lipid-doxorubicin prodrugs, and lipid-doxorubicin prodrug-based drug co-delivery nanosystems.Additionally, possible future research outlooks in this field were also discussed.

Source: Medicine Research

DOI: 10.21127/yaoyimr20200013

Authors: Filipe Olim, Ana Rute Neves, Zhao Wang, Jingjing Sun, Helena Tomás, and Ruilong Sheng

Institutions: Centro de Química da Madeira, Universidade da Madeira, Jinling Institute of Technology, University of Pittsburgh

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond