Work

Hydrogen peroxide induces Arl1 degradation and impairs Golgi-mediated trafficking

Year: 2020

Type: article

Abstract: H 2 O 2 treatment induces the degradation of Golgi structural proteins in the trans-Golgi, including Arl1, Golgin-97, and Golgin-245, and thereby impairs membrane trafficking. This study revealed the trans-Golgi and trafficking at the trans-Golgi as novel targets of ROS in cells.

Source: Molecular Biology of the Cell

DOI: 10.1091/mbc.e20-01-0063

Authors: Stephen C. Ireland, Haoran Huang, Jianchao Zhang, Jie Li, Yanzhuang Wang

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of General Medical Sciences