Work

Regioselective, Photocatalytic α-Functionalization of Amines

Year: 2020

Type: article

Abstract: Photocatalytic α-functionalization of amines provides a mild and atom-economical means to synthesize α-branched amines. Prior examples featured symmetrical or electronically biased substrates. Here we report a controllable α-functionalization of amines in which regioselectivity can be tuned with minor changes to the reaction conditions.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.0c03758

Authors: Lingying Leng, Yue Fu, Peng Liu, Joseph M. Ready

Institutions: The University of Texas Southwestern Medical Center, University of Pittsburgh

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, Welch Foundation, National Cancer Institute, National Institute of General Medical Sciences

Awards: G3226045097, Chemical Inhibitors of 15-prostaglandin dehydrogenase Potentiate Hematopoietic Stem Cell Transplantation, CAREER: Computational Studies of Transition Metal Catalyzed Reactions in Organic Synthesis, G7073091334, Computational Models for Reactivity and Selectivity in Catalytic Olefin Functionalization