Work

The lateral plate mesoderm

Year: 2020

Type: article

Abstract: The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo. Despite this central role in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM-derived tissues. Finally, we discuss the development of seemingly disparate organ systems that share a common LPM origin.

Source: Development

DOI: 10.1242/dev.175059

Authors: Karin D. Prummel, Susan Nieuwenhuize, Christian Mosimann

Institutions: University of Zurich, University of Colorado Anschutz, University of Colorado Denver

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Children's Hospital Colorado, Kanton Zürich, University of Colorado School of Medicine, Anschutz Medical Campus

OpenAlex ID: W3036555894