Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer
Year: 2020
Type: article
Abstract: OBJECTIVE: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. SUBJECTS AND METHODS: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. RESULTS: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. CONCLUSIONS: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.
Source: Oral Diseases
DOI: 10.1111/odi.13502
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Veterans Affairs, International Union Against Cancer, Memorial Sloan-Kettering Cancer Center, Johns Hopkins University, European Commission, Agence Nationale de la Recherche, Fundação de Amparo à Pesquisa do Estado de São Paulo, Fondation pour la Recherche Médicale, Fondation ARC pour la Recherche sur le Cancer, Oncosuisse, Fondation de France, Ministère des Affaires Sociales et de la Santé, Associazione Italiana per la Ricerca sul Cancro, Institut National Du Cancer, Fondazione Italiana per la Ricerca sul Cancro, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Institut de Veille Sanitaire, Swiss Cancer Research Foundation, National Institutes of Health, World Cancer Research Fund, National Institute on Drug Abuse, National Cancer Institute, Fogarty International Center, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research, Jonsson Comprehensive Cancer Center, Fondo para la Investigación Científica y Tecnológica, Institut Hospital del Mar d'Investigacions Mèdiques
Awards: G1008820181, G1017297203, G1067468845, G1089181893, G1131897597, G1158119171, G1263586908, G1338312080, G1672158201, G1864904867, G1882131324, G1903641494, G1917347058, G1926767755, G2062684063, G2067422786, G2432338990, G2488377645, G2598882791, G2654020657, G2738918960, G2772659363, G2781092678, CARCINOGEN METABOLIZING ENZYMES AND HEAD AND NECK CANCER, G2970275439, G2973696938, G3058848643, G3080600235, G342588646, G3475740106, Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas, G3673618048, Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe, G426964960, ALCOHOL AND CANCERS OF THE LARYNX AND ESOPHAGUS, UCLA SPORE IN LUNG CANCER, G435594446, G479108254, G4923405512, GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER, G504412488, G5138243688, G5256993890, Markers of aggressive behavior in head and neck tumors, G5610249917, G5810284131, G5956497116, LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS, G6081527584, ORAL CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, &IMMUNOLOGY, G6414039891, G6903844680, Epidemiology of protein glutathiolation, HPV AND RISK OF ORAL CANCER IN THE CZECH REPUBLIC, G7920079912, G8124029843, G8151339235, G8338893534, G8362657403, G8625312104, G9000014010, G9000093046, G9000099626, G9000131165, G9000145958, G9000152497, G9000179048, G9000208888, G9000215467, G9000229386, G9000312689, G9000346181, G9000350406, G9000351518
OpenAlex ID: W3036782113