Get started
Work

A systems genetics approach to revealing the Pdgfb molecular network of the retina.

Year: 2020
Type: article
Abstract: Purpose: Platelet-derived growth factor (PDGF) signaling is well known to be involved in vascular retinopathies. Among the PDGF family, the subunit B (PDGFB) protein is considered a promising therapeutic target. This study aimed to identify the genes and potential pathways through which PDGFB affects retinal phenotypes by using a systems genetics approach. Methods: was calculated based on the Pearson correlation coefficient. A gene set enrichment analysis and the STRING database were used to evaluate gene function and to construct protein-protein interaction (PPI) networks. Results: was directly connected to and interacted with other genes with similar biologic functions. Conclusions: regulation mechanism and potential therapy for vascular retinopathies.
Authors: Shasha Li, Fuyi Xu, Lin Liu, Rong Ju, Jonas Bergquist, Qing Yin Zheng, Jia Mi, Lu Lu, Xuri Li, Geng Tian
Institutions: Binzhou Medical University, University of Tennessee Health Science Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Uppsala University, Case Western Reserve University
Language: English
Open Access status: green
OpenAlex ID: W3037257440
FWCI: 0.081
Cites: 35
Cited by: 3
Related to: 10