Work

Atypical Presentation of Acquired Hypoganglionosis in a Patient Taking Clozapine

Year: 2020

Type: article

Abstract: Acquired hypoganglionosis (HG) is a rare enteric gastrointestinal neuromuscular disorder previously associated with chronic inflammation that can lead to constipation, ileus, and even death. There is little known about the pathophysiology of acquired hypoganglionosis, and it is unclear if medications are related to the development of the disease. Clozapine is an atypical antipsychotic used to treat refractory schizophrenia that is well known for its side effects including agranulocytosis and gastrointestinal dysmotility. This is an unusual case of acquired hypoganglionosis in a patient with anticholinergic toxicity on clozapine therapy.

Source: Case Reports in Gastrointestinal Medicine

DOI: 10.1155/2020/1272567

Authors: Catherine Gisi, Anamaria Munteanu, Lawrence Ku, Samuel French, Michael Fleischman, Viktor Eysselein

Institutions: University of California, Los Angeles, Harbor–UCLA Medical Center

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $790