Work

ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease

Year: 2020

Type: article

Abstract: ZBP1 triggers NLRP3 inflammasome activation/pyroptosis, apoptosis, and necroptosis; the specific ligand for ZBP1 activation remains ambiguous. Recent studies, including Devos et al. in this issue of JEM (https://doi.org/10.1084/jem.20191913), collectively suggest that ZBP1 sensing Z-nucleic acids is critical for cell death/inflammatory disease.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20200885

Authors: Sannula Kesavardhana, Thirumala-Devi Kanneganti

Institution: St. Jude Children's Research Hospital

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid