Association between plasma ceramides and hosphatidylcholines and hippocampal brain volume in late onset Alzheimer's disease
Year: 2017
Type: article
Study design: Observational Study
Abstract: Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer’s disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 p < 0.01, Cer18:0 p < 0.01, Cer24:1 p < 0.05). In addition, two PCs in AD plasma (PC36:5 p < 0.05, PC38:6 p < 0.05) were found to be depleted compared to the control group, with PC36:5 also associating with hippocampal atrophy (p < 0.01). Age-specific analysis further revealed that levels of Cer16:0, Cer18:0, and Cer20:0 were associated with hippocampal atrophy only in younger participants (age < 75, p < 0.05), while all 3 PCs did so in the older participants (age > 75, p < 0.05). PC36:5 was associated with AD status in the younger group (p < 0.01), while PC38:6 and 40:6 did so in the older group (p < 0.05). In this study, elevated ceramides and depleted PCs were found in the plasma from 205 AD volunteers. Our findings also suggest that dysregulation in PC and ceramide metabolism could be occurring in different stages of AD progression.
Authors: M. Kim, Alejo Nevado‐Holgado, Luke Whiley, Sean Snowden, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Madhav Thambisetty, Richard Dobson, John Powell, Michelle K. Lupton, A. Simmons, Latha Velayudhan, Simon Lovestone, Petroula Proitsi, Cristina Legido‐Quigley, Michelle M. Mielke, Pedro E. Martinez
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institute for Social Care and Health Research, South London and Maudsley NHS Foundation Trust, European Federation of Pharmaceutical Industries and Associations, Alzheimer's Society, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, King's College London, University College London, European Commission, Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council
Awards: G1073258374, G1099494159, Genomic variations underlying common behavior diseases and cognition trait in human populations, G1877862647, Centre for Health service and Academic Partnership in Translational eHealth Research (CHAPTER), G2473961061, G3207356259, G393177772, G4457630332, G5702163051, G6382720711, G6466690833, G7689853932, European Medical Information Framework
OpenAlex ID: W3038116272