Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition
Year: 2020
Type: article
Study design: Observational Study
Abstract: Background: Fatty acids impact obesity, estrogens, and inflammation, which are risk factors for ovarian cancer. Few epidemiologic studies have investigated the association of fatty acids with ovarian cancer. Methods: Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,486 incident ovarian cancer cases were identified. Cox proportional hazard models with adjustment for ovarian cancer risk factors were used to estimate HRs of ovarian cancer across quintiles of intake of fatty acids. False discovery rate was computed to control for multiple testing. Multivariable conditional logistic regression models were used to estimate ORs of ovarian cancer across tertiles of plasma fatty acids among 633 cases and two matched controls in a nested case–control analysis. Results: A positive association was found between ovarian cancer and intake of industrial trans elaidic acid [HR comparing fifth with first quintileQ5-Q1 = 1.29; 95% confidence interval (CI) = 1.03–1.62; Ptrend = 0.02, q-value = 0.06]. Dietary intakes of n-6 linoleic acid (HRQ5-Q1 = 1.10; 95% CI = 1.01–1.21; Ptrend = 0.03) and n-3 α-linolenic acid (HRQ5-Q1 = 1.18; 95% CI = 1.05–1.34; Ptrend = 0.007) from deep-frying fats were also positively associated with ovarian cancer. Suggestive associations were reported for circulating elaidic (OR comparing third with first tertileT3-T1 = 1.39; 95% CI = 0.99–1.94; Ptrend = 0.06) and α-linolenic acids (ORT3-T1 = 1.30; 95% CI = 0.98–1.72; Ptrend = 0.06). Conclusions: Our results suggest that higher intakes and circulating levels of industrial trans elaidic acid, and higher intakes of linoleic acid and α-linolenic acid from deep-frying fat, may be associated with greater risk of ovarian cancer. Impact: If causal, eliminating industrial trans-fatty acids could offer a straightforward public health action for reducing ovarian cancer risk.
Authors: Sahar Yammine, Inge Huybrechts, Carine Biessy, Laure Dossus, Elom K. Aglago, Sabine Naudin, Pietro Ferrari, Elisabete Weiderpass, Anne Tjønneland, Louise Hansen, Kim Overvad, Francesca R. Mancini, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Renée T. Fortner, Rudolf Kaaks, Matthias B. Schulze, Heiner Boeing, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Vassiliki Benetou, Giovanna Masala, Vittorio Krogh, Amalia Mattiello, Alessandra Macciotta, Inger T. Gram, Guri Skeie, Jose R. Quirós, Antonio Agudo, Maria-José Sánchez, Maria-Dolores Chirlaque, Eva Ardanaz, Leire Gil, Hanna Sartor, Isabel Drake, Annika Idahl, Eva Lundin, Dagfinn Aune, Heather Ward, Melissa A. Merritt, Naomi E. Allen, Marc J. Gunter, Véronique Chajès
Institutions: World Health Organization, Centre international de recherche sur le cancer, University of Copenhagen, Danish Cancer Society, Aarhus University, Université Paris-Sud, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, German Cancer Research Center, University of Potsdam, German Institute of Human Nutrition, Hellenic Health Foundation, National and Kapodistrian University of Athens, University General Hospital Attikon, University of Milan, Fondazione IRCCS Istituto Nazionale dei Tumori, Federico II University Hospital, University of Naples Federico II, University of Turin, UiT The Arctic University of Norway, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Basque Government, Biogipuzkoa Health Research Institute, Lund University, Umeå University, Oslo University Hospital, Oslo Nye Høyskole, Imperial College London, University of Hawaiʻi at Mānoa, University of Hawaii Cancer Center, University of Oxford
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
Funders: World Health Organization, Universitetet i Tromsø, Kræftens Bekæmpelse, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut National Du Cancer, Worldwide Cancer Research, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, Health and Medical Research Fund, Rijksinstituut voor Volksgezondheid en Milieu
Awards: G1049843548, G1090603134, G1200254525, G1241080153, G1344656563, G1767199718, G1788645866, G1907752718, G1952936224, G1993546569, G2149779140, G2149865848, G2216207056, G2235605558, G2257231888, G2372467518, G2445313629, G2539064604, G2561548287, G2611591051, G2709920838, G29072894, G2924980845, G3077395769, G3084320185, G3170664214, G3189789075, G331404038, G3452641779, G3461390129, G3544161537, G3675143906, G3747421453, G375319704, G3816092139, G3980646122, G4015156572, G4049848471, G4089957676, G4213141252, G423622538, G43956866, G459595259, G4682079261, G4811780622, G4884057766, G490534113, G5004963360, G5047213743, G5119219000, G5425491905, G5578953934, G558017500, G569908600, G5868006920, G5897142711, G5990830295, NIHR Senior Investigator Award, G6212483348, G6320156643, G640002926, G6457389867, G657255654, G6594529311, G6779186093, G6960682749, G7022277044, G7025202487, G7040807446, G7306252069, G7426181285, G7447125227, G7503396464, G7600088736, G7624991799, G7646326732, G8012318887, G8407261631, G8702800630, G876765158, G8867963557, G8978728421
OpenAlex ID: W3039015207